Selank Nasal spray 0.15% (15 mg) Nootropic peptide

Description

Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) , created as a derivative of the natural compound tuftsin. It is classified as a mild anxiolytic/nootropic : it reduces anxiety, increases stress resistance, and supports cognitive function without sedation or addiction. 

Peptide content  0.15% (15 mg)

How it works (mechanisms)

• GABA modulation : normalizes the functioning of the GABAergic system, thereby reducing anxiety without the “inhibition” typical of benzodiazepines. 
• Neuroplasticity : Increases BDNF expression and protects neurons from stress/hypoxia. 
• Anti-stress/anti-inflammation : Reduces pro-inflammatory cytokines, which correlates with better stress tolerance. 
• Complex nootropic action : long-lasting anxiolytic and cognitive effects have been demonstrated in preclinical and clinical studies. 

Who is it suitable for?

• High anxiety, internal tension, “nervous” insomnia.
• Periods of intense mental stress, studying, deadlines.
• Recovery from stress, overexertion, emotional burnout.
• As part of attention/memory support programs.

Advantages of the nasal spray format

• Rapid absorption through the nasal mucosa; delivery route optimal for CNS-targeted peptides.
• A number of sources report high bioavailability and rapid appearance in plasma (seconds to minutes) for the nasal form. 
• Convenient for courses and specific tasks (stressful day, public speaking, etc.).

Safety and tolerability

• Generally free of sedation and cognitive fog ; profile comparable to or milder than classical anxiolytics reported in publications. 
• Rare local reactions (dryness/tingling in the nose) are possible.
• Store at +2…+8 °C .
• Not a drug in many jurisdictions; use is for wellness/nootropic support.

Research:

• Clinical setting (GAD/non-plants): A comparative study in 62 patients: Selank (n=30) vs. medazepam (n=32). Comparable anxiolytic effects according to the Hamilton, Zung, and CGI scales , while Selank exhibited antiasthenic and psychostimulating effects . 
• Mechanism: GABA system Studies involving Selank show that the effect is linked to modulation of GABAergic transmission , which explains the anxiolytic profile without pronounced sedation. 
• Neuroprotection/BDNF Experiments have documented an increase in BDNF and memory protection in stress models—a neuroplastic contribution to the nootropic effect.
• Anti-stress immunomodulation Peptide reduces pro-inflammatory cytokines during “social stress” in animals – a biological link in the anti-stress effect. 
• Formula/Sequence and Review Detailed review of the molecular aspects of Selank (TKPRPGP sequence, long-lasting anxiolytic/nootropic effects). 
• Nasal delivery For peptides like Selank, the nasal route is considered optimal for reaching the CNS; indications include high systemic availability and rapid appearance in the blood. 

Selank 10 ml is a mild anxiolytic-nootropic: it reduces anxiety, improves concentration, and enhances stress resistance. It’s a fast-acting nasal spray with no sedation.

Basic (anxiety/stress):

• 1–2 sprays in  each  nostril,  2–3 times a day , course  10–14 days .

Nootropic (attention/memory):

• 1–2 sprays in each nostril  1–2 times/day , course  2–4 weeks , repeat 3–4 times/year.

Prevention/support:

• 1–2 injections  1 time/day , 2–3 weeks, then a break of 1–2 weeks.

Selank (TKPRPGP)