Epitalon Spray – pineal gland AEDG peptides 10mg/20mg

Description

EPITHALON  (Pineal gland peptide) synthetic pineal tetrapeptide, telomerase activator and potential anti-aging drug developed at the St. Petersburg Institute of Bioregulation and Gerontology in the scientific group of Corr. RAS, prof. Khavinson V.Kh. The peptide was obtained by targeted design based on the amino acid analysis of epithalamin (a pineal gland preparation, a bioregulator of the neuroendocrine system, which is the sum of peptides isolated from the epithalamic-epiphyseal region of the bovine brain) and has the following sequence: Ala-Glu-Asp-Gly.

The pineal gland is an important endocrine gland located in the vast majority of vertebrates in the brain. The pineal gland produces many regulatory compounds, including the neurotransmitter melatonin, which is responsible for sleep and the duration of its individual phases, as well as affecting seasonal and circadian cycles and having an antioxidant effect and stimulating – in relation to immunity.

Preparations of the pineal gland normalize various processes in the human body. Experimental results confirm that short peptides of the pineal gland enhance the antioxidant defense system, which may contribute to their geroprotective properties.

A clinical study of epithalamin demonstrated improvement in key parameters in elderly and senile patients and reduced mortality over a 15-year follow-up period. This indicates that pineal gland peptides may find application in clinical practice. Research in the field of directed differentiation of stem cells using peptide regulation is of particular importance for the development of innovative approaches to molecular medicine and therapy at the cellular level.

It is also obvious that synthetic methods for obtaining peptides are of the highest priority and allow not only obtaining high-purity products, but also modifying their molecular structure, significantly enhancing the beneficial properties of the drug.

Application: Epithalon is a very promising drug for the treatment of a number of serious diseases, including pulmonary tuberculosis and some types of cancer. Epitalon also exhibits pronounced anti-aging properties and can significantly improve the quality of life of elderly patients. This effective bioregulator with a wide spectrum of biological activity and low toxicity may find even greater application in the future.

Quantity: 10 ml

Peptide content: 10mg / 20mg

Purity: over 97%

Form: solution in spray dispenser

Excipient: purified water, sodium chloride, methylparaben

Storage: no more than +5C

Amino acid sequence: Ala-Glu-Asp-Gly

Molecular weight: 390.35

Molecular formula: C₁₄H₂₂N₄O₉

Synonyms: Эпиталон, Эпиталамин, Epitalon, Epytalamin, AGAG, AEDG

Main area of research: telomerase activity, gerontology, oncology, pineal and thymus activity, immunity.

KHAVINSON PEPTIDES® technology   has been used since 1973, with numerous studies published in PubMed. Scientifically proven and effective.

Recommended for: 

• Problems with melatonin production;
• Disruption of human biorhythms;
• Sleep disorders, insomnia;
• Jet lag (sleep disturbance after long flights);
• Fatigue, stress;
• Weakened immunity.
• Normalization of the function of the neuroendocrine system
• Normalization of all cyclic processes in the body
• Synchronization of biological clocks
• Normalization of the reproductive system
• Delay and smoothing of menopause manifestations
• Increasing fertility (ability to bear children)
• Prevention of tumors, especially of the reproductive system (reduces risk up to 5 times)
• Normalization of immunity and antioxidant status
• Increasing life expectancy

Numerous clinical studies have proven the effectiveness of Epitalon. You can read about the clinical studies of Epitalon  here .

Spray 3 times under the tongue 2 times a day before meals in the morning and afternoon for 20 days. It is recommended to repeat the course every 4-6 months.

Research:

It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis. AEDG peptide induces neuronal cell differentiation in retinal and human periodontal ligament stem cells. The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process. AEDG peptide increased the synthesis of neurogenic differentiation markers: Nestin, GAP43, β Tubulin III, Doublecortin in hGMSCs. AEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6–1.8 times in hGMSCs. Molecular modelling method showed, that AEDG peptide preferably binds with H1/6 and H1/3 histones in His-Pro-Ser-Tyr-Met-Ala-His-Pro-Ala-Arg-Lys and Tyr-Arg-Lys-Thr-Gln sites, which interact with DNA. These results correspond to previous experimental data. AEDG peptide and histones H1/3, H1/6 binding may be one of the mechanisms which provides an increase of Nestin, GAP43, β Tubulin III, and Doublecortin neuronal differentiation gene transcription. AEDG peptide can epigenetically regulate neuronal differentiation gene expression and protein synthesis in human stem cells.